The ISO large flange standard is known as LF, LFB, MF or sometimes just ISO flange. As in KF-flanges, the flanges are joined by a centering ring and an elastomeric o-ring. An extra spring-loaded circular clamp is often used around the large-diameter o-rings to prevent them from rolling off from the centering ring during mounting.

The ISO large flanges come in two varieties. The ISO-K (or ISO LF) flanges are joined with double-claw clamps, which clamp to a circular groove on the tubing side of the flange. The ISO-F (or ISO LFB) flanges have holes for attaching the two flanges with bolts. Two tubes with ISO-K and ISO-F flanges can be joined together by clamping the ISO-K side with single-claw clamps, which are then bolted to the holes on the ISO-F side.

ISO large flanges are available in sizes from 63 to 500 mm nominal tube diameter.